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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIK2
All Species:
14.85
Human Site:
Y679
Identified Species:
29.7
UniProt:
Q9H0K1
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H0K1
NP_056006.1
926
103915
Y679
R
Q
S
L
E
T
Q
Y
L
Q
H
R
L
Q
K
Chimpanzee
Pan troglodytes
XP_508750
883
99166
Y636
R
Q
S
L
E
T
Q
Y
L
Q
H
R
L
Q
K
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_546528
993
110460
Y753
R
Q
S
L
E
A
Q
Y
L
Q
H
R
L
Q
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8CFH6
931
104180
Y679
Q
Q
S
L
E
T
Q
Y
L
Q
H
R
L
Q
K
Rat
Rattus norvegicus
Q9R1U5
776
84890
Q555
Q
S
A
T
P
V
L
Q
S
Q
A
G
L
G
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511894
801
88312
A581
S
F
Q
E
G
R
R
A
S
D
T
S
L
T
Q
Chicken
Gallus gallus
Q9IA88
798
88848
S578
G
R
R
A
S
D
T
S
L
T
Q
G
L
K
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
G872
L
K
V
P
G
L
E
G
Y
G
L
S
Y
G
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_569972
1398
149888
H1133
L
L
T
L
P
H
H
H
A
H
P
A
Q
H
H
Honey Bee
Apis mellifera
XP_397175
718
80391
S498
C
T
P
P
P
P
M
S
P
S
P
I
T
G
R
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
Q914
S
S
T
G
A
S
S
Q
Q
Y
H
P
K
A
P
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
K292
P
D
T
V
E
Q
A
K
K
I
N
E
E
I
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.2
N.A.
84.7
N.A.
90.8
43.2
N.A.
45.2
45.4
N.A.
31.5
N.A.
29.6
37.4
23.8
N.A.
Protein Similarity:
100
95.3
N.A.
87.5
N.A.
94.4
56.7
N.A.
58.6
58.9
N.A.
45.2
N.A.
40
49.3
38.1
N.A.
P-Site Identity:
100
100
N.A.
93.3
N.A.
93.3
13.3
N.A.
6.6
13.3
N.A.
0
N.A.
6.6
0
6.6
N.A.
P-Site Similarity:
100
100
N.A.
93.3
N.A.
100
26.6
N.A.
20
26.6
N.A.
13.3
N.A.
20
6.6
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
24.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.4
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
9
9
9
9
9
9
0
9
9
0
9
17
% A
% Cys:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
0
0
0
9
0
0
0
9
0
0
0
0
0
% D
% Glu:
0
0
0
9
42
0
9
0
0
0
0
9
9
0
0
% E
% Phe:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
9
0
0
9
17
0
0
9
0
9
0
17
0
25
9
% G
% His:
0
0
0
0
0
9
9
9
0
9
42
0
0
9
9
% H
% Ile:
0
0
0
0
0
0
0
0
0
9
0
9
0
9
0
% I
% Lys:
0
9
0
0
0
0
0
9
9
0
0
0
9
9
34
% K
% Leu:
17
9
0
42
0
9
9
0
42
0
9
0
59
0
0
% L
% Met:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% N
% Pro:
9
0
9
17
25
9
0
0
9
0
17
9
0
0
9
% P
% Gln:
17
34
9
0
0
9
34
17
9
42
9
0
9
34
9
% Q
% Arg:
25
9
9
0
0
9
9
0
0
0
0
34
0
0
9
% R
% Ser:
17
17
34
0
9
9
9
17
17
9
0
17
0
0
0
% S
% Thr:
0
9
25
9
0
25
9
0
0
9
9
0
9
9
0
% T
% Val:
0
0
9
9
0
9
0
0
0
0
0
0
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
34
9
9
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _